Chronic low-grade inflammation sensitizes nociceptors and accelerates degenerative joint changes. Damping NF-κB signaling reduces pain while sparing gut and renal side-effects common to NSAIDs. Turmeric curcuminoids and quercetin directly inhibit COX-2 and down-regulate pro-inflammatory cytokines. Carnitine, magnesium glycinate, and marine omega-3s supply mitochondrial fuel and membrane eicosanoid competitors, further easing musculoskeletal discomfort.