Elevated homocysteine impairs vascular elasticity and slows neurotransmitter synthesis. Efficient one-carbon metabolism keeps these pathways clear and DNA repair humming. Methyl B-complex delivers bioactive folate and B12, with trace minerals and magnesium acting as enzyme cofactors for SAMe generation. Fat-soluble ADEK vitamins stabilize cellular membranes, allowing renewed methyl donors to fine-tune epigenetic expression.